國外小組科研—化學(xué)綜合專題：化學(xué)物質(zhì)對機體的毒副作用機制與評價，以氰化物、百草枯等為例

開始日期：

2023年6月24日

專業(yè)方向：

理工

導(dǎo)師：

Charles（威廉姆斯學(xué)院 Williams College 講席終身正教授）

課程周期：

7周在線小組科研學(xué)習(xí)+5周不限時論文指導(dǎo)學(xué)習(xí)

語言：

英文

建議學(xué)生年級：

大學(xué)生 高中生

項目產(chǎn)出：

7周在線小組科研學(xué)習(xí)+5周不限時論文指導(dǎo)學(xué)習(xí) 共125課時 項目報告 優(yōu)秀學(xué)員獲主導(dǎo)師Reference Letter EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等級別索引國際會議全文投遞與發(fā)表指導(dǎo)（可用于申請） 結(jié)業(yè)證書 成績單

項目介紹：

本項目將帶領(lǐng)學(xué)生學(xué)習(xí)生物標(biāo)志物、毒性標(biāo)準(zhǔn)和評價、在生物體內(nèi)的代謝途徑、化學(xué)反應(yīng)、以及對機體的影響，并深入到毒素對DNA的影響與致病性。學(xué)生將通過項目了解化學(xué)物質(zhì)毒理學(xué)經(jīng)典理論概念，毒性評價及其與生命系統(tǒng)的相互作用，思考在環(huán)境、公共衛(wèi)生、食品安全等各個領(lǐng)域的應(yīng)用。課程中將列舉大量化學(xué)物質(zhì)實例，逐一剖析它們的化學(xué)性質(zhì)以及危險因素。在項目結(jié)束時提交報告，進行成果展示。? 個性化研究課題參考：水飛薊素對丙烯酰胺所致PC12細胞氧化損傷的保護作用、不同種蘆薈植物化學(xué)物組成及抗紫外損傷機理探究、氯化鎘、硫酸鋅和亞硒酸鈉的體外細胞毒性 This program will lead students to learn biomarkers, toxicity criteria and evaluation, metabolic pathways in organisms, chemical reactions, and effects on the body, and in-depth into the effects of toxins on DNA and pathogenicity. Through the project, students will understand the classical theoretical concepts of chemical toxicology, toxicity evaluation and its interaction with living systems, and think about the application in various fields such as environment, public health and food safety. A large number of examples of chemicals will be presented and their chemical properties and risk factors will be analyzed one by one. Students will understand the classic theories and concepts of biochemical toxicology, toxicity and its interaction with life systems through the project, and submit a report at the end of the project to demonstrate their results. Suggested Future Research Fields: Protective effect of silymarin on oxidative damage of PC12 cells induced by acrylamide, Study on the composition of different kinds of aloe phytochemicals and their anti-ultraviolet damage mechanism, In vitro cytotoxicity of cadmium chloride, zinc sulfate and sodium selenite