博雅計劃—博雅計劃：化學(xué)綜合專題：化學(xué)物質(zhì)對機(jī)體的毒副作用機(jī)制與評價，以氰化物、百草枯等為例

開始日期：

2023年6月24日

專業(yè)方向：

理工

導(dǎo)師：

Charles（威廉姆斯學(xué)院 Williams College 講席終身正教授）

課程周期：

7周在線小組科研+5周論文輔導(dǎo)

語言：

英文

建議學(xué)生年級：

大學(xué)生

項目產(chǎn)出：

7周在線小組科研學(xué)習(xí)+5周論文指導(dǎo)學(xué)習(xí) 學(xué)術(shù)報告 EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等級別索引國際會議全文投遞與發(fā)表指導(dǎo)（共同一作） 結(jié)業(yè)證書 成績單

項目介紹：

本項目將帶領(lǐng)學(xué)生學(xué)習(xí)生物標(biāo)志物、毒性標(biāo)準(zhǔn)和評價、在生物體內(nèi)的代謝途徑、化學(xué)反應(yīng)、以及對機(jī)體的影響，并深入到毒素對DNA的影響與致病性。學(xué)生將通過項目了解化學(xué)物質(zhì)毒理學(xué)經(jīng)典理論概念，毒性評價及其與生命系統(tǒng)的相互作用，思考在環(huán)境、公共衛(wèi)生、食品安全等各個領(lǐng)域的應(yīng)用。課程中將列舉大量化學(xué)物質(zhì)實例，逐一剖析它們的化學(xué)性質(zhì)以及危險因素。在項目結(jié)束時提交報告，進(jìn)行成果展示。? 個性化研究課題參考：水飛薊素對丙烯酰胺所致PC12細(xì)胞氧化損傷的保護(hù)作用、不同種蘆薈植物化學(xué)物組成及抗紫外損傷機(jī)理探究、氯化鎘、硫酸鋅和亞硒酸鈉的體外細(xì)胞毒性 This program will lead students to learn biomarkers, toxicity criteria and evaluation, metabolic pathways in organisms, chemical reactions, and effects on the body, and in-depth into the effects of toxins on DNA and pathogenicity. Through the project, students will understand the classical theoretical concepts of chemical toxicology, toxicity evaluation and its interaction with living systems, and think about the application in various fields such as environment, public health and food safety. A large number of examples of chemicals will be presented and their chemical properties and risk factors will be analyzed one by one. Students will understand the classic theories and concepts of biochemical toxicology, toxicity and its interaction with life systems through the project, and submit a report at the end of the project to demonstrate their results. Suggested Future Research Fields: Protective effect of silymarin on oxidative damage of PC12 cells induced by acrylamide, Study on the composition of different kinds of aloe phytochemicals and their anti-ultraviolet damage mechanism, In vitro cytotoxicity of cadmium chloride, zinc sulfate and sodium selenite