博雅計(jì)劃—博雅計(jì)劃：生物化學(xué)專(zhuān)題：阿司匹林、對(duì)乙酰氨基酚等藥物對(duì)人體代謝系統(tǒng)、細(xì)胞活動(dòng)和基因表達(dá)的影響綜合研究

開(kāi)始日期：

2023年6月24日

專(zhuān)業(yè)方向：

理工

導(dǎo)師：

Charles（威廉姆斯學(xué)院 Williams College 講席終身正教授）

課程周期：

7周在線小組科研+5周論文輔導(dǎo)

語(yǔ)言：

英文

建議學(xué)生年級(jí)：

大學(xué)生

項(xiàng)目產(chǎn)出：

7周在線小組科研學(xué)習(xí)+5周論文指導(dǎo)學(xué)習(xí) 學(xué)術(shù)報(bào)告 EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等級(jí)別索引國(guó)際會(huì)議全文投遞與發(fā)表指導(dǎo)（共同一作） 結(jié)業(yè)證書(shū) 成績(jī)單

項(xiàng)目介紹：

本項(xiàng)目將帶領(lǐng)學(xué)生學(xué)習(xí)生物標(biāo)志物、毒性標(biāo)準(zhǔn)和評(píng)價(jià)、在生物體內(nèi)的代謝途徑、化學(xué)反應(yīng)、以及對(duì)機(jī)體的影響，并深入到毒素對(duì)DNA的影響與致病性。學(xué)生將通過(guò)項(xiàng)目了解化學(xué)物質(zhì)毒理學(xué)經(jīng)典理論概念，毒性評(píng)價(jià)及其與生命系統(tǒng)的相互作用，思考在環(huán)境、公共衛(wèi)生、食品安全等各個(gè)領(lǐng)域的應(yīng)用。課程中將列舉大量化學(xué)物質(zhì)實(shí)例，逐一剖析它們的化學(xué)性質(zhì)以及危險(xiǎn)因素。在項(xiàng)目結(jié)束時(shí)提交報(bào)告，進(jìn)行成果展示。 個(gè)性化研究課題參考：水飛薊素對(duì)丙烯酰胺所致PC12細(xì)胞氧化損傷的保護(hù)作用、不同種蘆薈植物化學(xué)物組成及抗紫外損傷機(jī)理探究、氯化鎘、硫酸鋅和亞硒酸鈉的體外細(xì)胞毒性 This program will lead students to learn biomarkers, toxicity criteria and evaluation, metabolic pathways in organisms, chemical reactions, and effects on the body, and in-depth into the effects of toxins on DNA and pathogenicity. Through the project, students will understand the classical theoretical concepts of chemical toxicology, toxicity evaluation and its interaction with living systems, and think about the application in various fields such as environment, public health and food safety. A large number of examples of chemicals will be presented and their chemical properties and risk factors will be analyzed one by one. Students will understand the classic theories and concepts of biochemical toxicology, toxicity and its interaction with life systems through the project, and submit a report at the end of the project to demonstrate their results. Suggested Future Research Fields: Protective effect of silymarin on oxidative damage of PC12 cells induced by acrylamide, Study on the composition of different kinds of aloe phytochemicals and their anti-ultraviolet damage mechanism, In vitro cytotoxicity of cadmium chloride, zinc sulfate and sodium selenite