博雅計(jì)劃—博雅計(jì)劃：生命科學(xué)與生物醫(yī)學(xué)課題：從細(xì)胞的穩(wěn)態(tài)和應(yīng)激角度，探究阿茨海默癥等疾病的發(fā)病原理

開始日期：

2023年6月24日

專業(yè)方向：

理工

導(dǎo)師：

S.C. （布朗大學(xué) Brown University 終身教授）

課程周期：

7周在線小組科研+5周論文指導(dǎo)

語言：

英文

建議學(xué)生年級：

大學(xué)生

項(xiàng)目產(chǎn)出：

7周在線小組科研學(xué)習(xí)+5周論文指導(dǎo)學(xué)習(xí) 學(xué)術(shù)報(bào)告 EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等級別索引國際會議全文投遞與發(fā)表指導(dǎo)（共同一作） 結(jié)業(yè)證書 成績單

項(xiàng)目介紹：

本項(xiàng)目將從細(xì)胞基礎(chǔ)結(jié)構(gòu)入手，探究內(nèi)質(zhì)網(wǎng)內(nèi)穩(wěn)態(tài)，內(nèi)質(zhì)網(wǎng)的結(jié)構(gòu)和功能，人類疾病中的ER應(yīng)激和未折疊蛋白質(zhì)反應(yīng)，分析細(xì)胞死亡模式和疾病之間的關(guān)系，自噬性的調(diào)節(jié)在人類疾病中的作用等。項(xiàng)目以阿爾茨海默氏病、帕金森氏病等神經(jīng)退行性疾病，Cov-19為例，帶領(lǐng)學(xué)生探究細(xì)胞機(jī)制與疾病發(fā)病之間的關(guān)系。通過本項(xiàng)目的學(xué)習(xí)，學(xué)生將進(jìn)一步了解維持細(xì)胞正常形態(tài)結(jié)構(gòu)、功能和代謝的重要意義，在項(xiàng)目結(jié)束時(shí)提交報(bào)告，進(jìn)行成果展示。 個(gè)性化研究課題參考： 脂質(zhì)組學(xué)揭示病毒感染引起的脂代謝異常及潛在治療靶點(diǎn) 血管平滑肌細(xì)胞收縮的分子機(jī)制研究進(jìn)展 細(xì)胞焦亡參與動(dòng)脈粥樣硬化形成的分子機(jī)制新進(jìn)展? ?This project will start with the cellular infrastructure, explore the homeostasis of the endoplasmic reticulum, the structure and function of the endoplasmic reticulum, the ER stress and unfold protein response in human diseases, and analyze the relationship between cell death patterns and diseases. The role of phagocytic regulation in human diseases, etc. The project takes Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases, Cov-19 as an example, and leads students to explore the relationship between cell mechanisms and disease onset. Through the study of this project, students will further understand the importance of maintaining the normal shape, structure, function and metabolism of cells, and submit a report at the end of the project to demonstrate the results.? ?Suggested Future Research Fields：Lipidomics reveals abnormal lipid metabolism caused by viral infection and potential therapeutic targets Research progress on the molecular mechanism of vascular smooth muscle cell contraction New progress in the molecular mechanism of pyroptosis involved in the formation of atherosclerosis